Identification of the process of abnormal expression of pancreatic cancer cells…expectation of new treatment strategies
Posted on 14.01.2024 at 18:45 Views 279 Posted on 14.01.2024 at 18:45 Modified on 15.01.2024 00:50 Views 279
Recently, a research team at the Faculty of Medicine of Ajou University identified for the first time the principles and processes by which basal-like pancreatic cancer occurs. [사진=게티이미지뱅크]Currently, pancreatic cancer is classified into two types (subtypes): “classic” and “basal-like”. The basic type of pancreatic cancer also has a low cure rate, but especially the basal type is considered “malignant”. This is because the patient mortality rate is significantly high due to high resistance to treatment.
Recently, a research team at the Faculty of Medicine of Ajou University identified for the first time the principles and processes by which basal-like pancreatic cancer occurs. According to this, basal type pancreatic cancer creates a specific environment at the cellular level and rarely develops into basal type.
The research team found that the expression of “TAp63,” one of the genetic proteins that induce tumor formation, was increased in basal-type pancreatic cancer. TAp63 is the same type as “TP63,” a gene frequently found in aggressive, highly metastatic pancreatic cancer. The tumor protein called “P63” produced by this gene suppresses the autoimmune function of cells and prevents our body from killing cancer cells.
Furthermore, the pathway that signals tumor cells to express TAp63 was also identified. This occurred through a signaling pathway called “NF-κB”. In particular, at this time, the signal sent by the tumor cells attacked the “macrophages”, one of the main immune cells, through different pathways. This signal acts around the macrophages, causing hypoxia and strengthening the inflammatory response, creating an environment for the TAp63 protein to infiltrate (express) inside the macrophages.
In other words, it neutralizes macrophages, which play the role of feeding on harmful substances that infiltrate or present themselves in the body (autophagic immune function). Therefore, basal-type pancreatic cancer is less resistant to treatment than basal-type pancreatic cancer and has a higher metastatic potential.
Professor Lee Da-geun from the Department of Pathology at Ajou University School of Medicine said: “Contrary to existing expectations, stimulation (extracellular stimulation) originating from tumor cells, not the patient’s own cells, determined the molecular subtype of tumor cells”. he added: “The cellular environment surrounding tumor cells and their interactions.” The importance of the tumor microenvironment has been demonstrated once again,” he said.
Professor Yuseon Kim from the Department of Biochemistry of the same university said: “I hope that the new strategy targeting the process identified this time (macrophage infiltration → tumor necrosis factor → TAp63 expression → basal-type pancreatic cancer formation) will contribute to the treatment .”
The article was published in the online edition of Clinical and Translational Medicine, an international SCI-level academic journal. The full text can be found at the following link (
Meanwhile, this research was supported by the Outstanding Younger Support Project of the National Research Foundation of Korea, the Creative Challenge Support Project, the Mid-career Researcher Support Project, and the Basic Research Laboratory (BRL).
Journalist Choi Ji-hyeon
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2024-01-14 09:46:51
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