Herbal medicine “Appalak” and raw material loofah cucumber
As we are about to enter a very aging society, new senior trends such as “Generation A” and “Generation YOLD” are emerging, which focus on the elderly. As a result, older people pay great attention to “aging well” and spare no investment in healthcare. However, the loss of muscle mass with aging and the resulting risk of degenerative musculoskeletal diseases often hinder older adults. In fact, according to the Health Insurance Review and Evaluation Service, the number of patients visiting medical institutions with sarcopenia has increased by approximately 56% over the past three years (2020-2022).
Since sarcopenia is a disease that has been officially assigned a disease code, it increases the risk of diseases such as diabetes, cardiovascular disease and depression, as well as of the musculoskeletal system. There are also statistics that show that patients with musculoskeletal diseases such as degenerative disc disease and osteoarthritis who suffer from sarcopenia have a higher mortality rate than ordinary patients because the weakened muscles cannot adequately support the bones and joints. According to a study conducted by a national university, men over the age of 65 with sarcopenia had a mortality rate more than four times that of ordinary men.
Therefore, older adults suffering from musculoskeletal degeneration should pay particular attention to muscle loss. However, steroid drugs, which are the main treatment of musculoskeletal diseases, have been reported to cause muscle atrophy and muscle loss when taken for long periods of time and at high doses. As a result, research into treatments without side effects is actively being conducted.
Meanwhile, the research team of the Spine and Joint Research Institute of Jaseng Oriental Medicine Hospital (director Ha In-hyuk) and researcher Yeo Chang-hwan announced on the 27th that they confirmed that the herbal medicine “Saguarak” promotes muscle formation and prevents muscle atrophy and the relevant mechanism was demonstrated for the first time. The article was published in the international academic journal SCI(E) level “Journal of Muscle Research and Cell Motility (IF=3.352)”.
Researcher Yeo Chang-hwan, Spine and Joint Research Institute, Jaseng Hospital of Oriental Medicine
Luffa cylindrica Roemer (scientific name: Luffa cylindrica Roemer), which is dried by removing the seeds and peel from the fruit of the luffa cucumber of the Cucurbitaceae family, is a herbal medicine used since ancient times to relieve fever, bleeding and l ‘inflammation . Recently, research results have shown that ingredients such as phenolic acids and flavonoids contained in green apples promote protein synthesis and muscle growth, and the possibility of its use as a treatment for muscular dystrophy is being discussed.
Accordingly, the research team treated muscle tissue isolated from experimental mice with a high dose of “dexamethasone”, a steroid drug, to induce muscle atrophy, and then treated it with apple tree extract at concentrations of 100 , 200 and 400 μg. /ml. As a result, it was confirmed that the higher the concentration of apple stone, the more activated the muscle cells. Green apple leaves increased the survival rate of muscle cells, promoted cell proliferation, and showed a protective effect against muscle cell death caused by dexamethasone.
Even in the process of muscle formation, the size and number of “myotubal cells,” the cells that form muscle fibers, increased significantly in proportion to the concentration of green apple leaves. First, in an experiment conducted on cells not treated with dexamethasone, comparing the average degree of myotubal cell formation in each experimental group, the group treated with 400 μg/mL of green apple extract, which had the highest concentration, improved more than twice that of the untreated group. Through this, the research team analyzed that apple rock effectively helps in muscle formation and growth.
As the apple concentration increases, the size and number of myotubal cells return closer to normal.
In a subsequent experiment with dexamethasone treatment, green apples significantly suppressed the levels of the muscle atrophy-inducing proteins “Atrogin-1” and “MuRF1 (Muscle RING-finger protein-1)” and reduced size of myotubal cells. to restore the water. Notably, the group treated with 400 μg/mL green apple improved myotubal cells to a similar level as the normal group compared to the dexamethasone-treated group. This means that apples have a protective effect against muscle atrophy.
Researcher Yeo Chang-hwan, the paper’s first author, said: “This study is significant as it is the first to demonstrate the protective effect of Saguarok against muscle atrophy.” study can be used to prevent muscle atrophy without side effects in the future.” “I hope this can help develop treatments for muscle wasting and muscle wasting,” he said.
The article was published in the “Journal of Muscle Research and Cell Motility (IF=3.352)”
Reporter Kang Seok-bong [email protected]
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2023-12-30 01:08:00
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