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“Calorie restriction” diets that reduce food intake are known to slow aging and increase lifespan. An American research team has discovered that a specific food gene called “OXR1” plays a role here.
The Buck Institute in the US has published research results in fruit flies and human cells showing that OXR1 plays a role in low-calorie diets by extending lifespan and slowing brain aging. The results of this study were published on the 11th in the international academic journal “Nature Communications”.
The team conducted extensive testing to determine how this gene, active in neurons, affects overall lifespan, and the results showed that OXR1 affects “retromers,” protein complexes essential for the recycling of cellular proteins and lipids . Retromere dysfunction is known to be associated with age-related neurodegenerative diseases, particularly Alzheimer’s disease and Parkinson’s disease.
The research team also analyzed that dietary habits aimed at reducing food intake improved the expression of OXR1. The research team said: “Diet influences this gene” and “Eating less food strengthens the mechanism by which proteins are correctly sorted in cells and improves the expression of OXR1.”
The research team also found that increasing a diet-specific gene (OXR1 gene) known as “mtd” in fruit flies increases the lifespan of fruit flies. This suggests that, in humans, strong expression of OXR1 may help extend lifespan. “Our next step is to find specific compounds that delay brain aging and extend lifespan by increasing OXR1 levels,” the research team said.
[조선일보와 미디어DX가 공동 개발한 생성형 AI의 도움을 받아 작성한 기사입니다.]
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2024-01-17 01:00:57
#Eating #slows #brain #aging #extends #lifespan